This Analyst Sees Recovery For PolyPid Despite Failed Phase 3 Readout

Raymond James downgraded PolyPid Ltd (NASDAQ:PYPD) from Strong Buy to Outperform post SHIELD I Phase 3 results that, despite consistency and evidence of…
  • Raymond James downgraded PolyPid Ltd (NASDAQ:PYPD) from Strong Buy to Outperform post SHIELD I Phase 3 results that, despite consistency and evidence of efficacy demonstrated to date, failed to achieve the primary endpoint. 
  • It lowered the price target from $15 to $4.
  • The analyst says that though the price reaction was not surprising, it has marked valuation down to effectively cash, the traditional initial stopping point in sell-offs.
  • Related: PolyPid’s Lead Program Flunks Abdominal Surgery Study, Shares Tank.
  • The analyst reduced the associated probability of success based on elevated regulatory uncertainty from 80% POS to 20%. 
  • Raymond James also notes that the Data Safety Monitoring Board conducted an interim analysis and recommended early cessation of trial recruitment, an action believed to signal a favorable full readout in light of historical 60%-plus efficacy rates.
  • The analyst says that as PolyPid can further expand to other drug actives utilizing its proprietary PLEX technology platform, the current price levels afford attractive accumulation points, with multiple upcoming inflection points for investors.
  • Price Action: PYPD shares are down 16.1% at $1.20 on the last check Tuesday.
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Maryland residents spent a record $96.5m on cannabis products in December, according to data from the Maryland Cannabis Administration (MCA). Of that total, $61.5m came from recreational cannabis sales, while medical sales totaled around $35m for the month. Maryland has seen booming sales since the launch of the recreational market last summer. At the time, existing cannabis companies in the state switched to adult-use shops by paying an 8% one-time fee of their 2022 dispensary revenue not exceeding $2m. Licensed stores took in $20.9m in the first week of legal sales. In total, Maryland recorded $787.5m in sales of legal marijuana products in 2023. Over the same period, Rhode Islanders spent more than $107.8m on combined cannabis sales.

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