- SQZ Biotechnologies Company (NYSE:SQZ) announced that a confirmed complete response was observed in the first patient in the lowest-dose cohort of the Phase 1 SQZ-AAC-HPV-101 trial.
- The second and third patients have also been enrolled in the trial.
- The company has completed the dose-limiting toxicity period for the lowest-dose cohort.
- The Study Safety Committee has completed its review and recommends that the company enroll patients in the highest dose cohort.
- The company anticipates initial clinical data from the highest-dose cohort by the fourth quarter of 2023.
- The 61-year-old male patient has a history of metastatic HPV16+ rectal squamous cell carcinoma. The patient had two prior lines of treatment but had not been treated with immune checkpoint inhibitors.
- The patient remains on the study, and the treatment has been well tolerated.
- In December 2022, after two cycles of SQZ-AAC-HPV, a CT scan showed a reduction of the target lesion to meet RECIST 1.1 criteria for a partial response.
- In February 2023, after four cycles of SQZ-AAC-HPV, a CT scan showed further reduction of the target lesion.
- In March 2023, after seven cycles of SQZ-AAC-HPV, a CT scan confirmed the complete response.
- SQZ Biotechnologies ended FY22 with a cash balance of $63.7 million, sufficient to runway into 2024.
- Price Action: SQZ shares are up 18.80% at $0.72 during the premarket session on the last check Thursday.
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