- Needham previews the upcoming Phase 2 data readout for Neurocrine Biosciences Inc’s (NASDAQ:NBIX) NBI-827104, a t-type calcium channel blocker in essential tremor (ET), by mid-2022.
- The analyst notes that though NBI-827104 lags behind its competitors, the market opportunity will be attractive given the total addressable market estimated at ~$13 billion, with no recently approved drugs in ET.
- The following data readout for Jazz Pharmaceuticals PLC (NASDAQ:JAZZ) and Praxis Precision Medicines Inc’s (NASDAQ:PRAX) second Phase 2 trials are expected in 1H of 2024 and 2H of 2022, respectively.
- Commenting on efficacy, given a similar mechanism of action to Jazz’s JZP385 and Praxis’ PRAX-944, Needham looks for a change in TETRAS-ADL of 5-6 points and TETRAS-ADL of 4-5 points.
- TETRAS is designed for the rapid and valid assessment of ET severity.
- On safety, JZP385 and PRAX-944 both had ~20% discontinuations.
- The analyst says that if NBI-827104’s safety profile can replicate its Phase 1 (~10% discontinuation).
- Needham expects a single-digit upside to shares on a successful study.
- Price Action: NBIX shares are up 1.77% at $97.26 during the market session on the last check Monday.
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