- Assembly Biosciences Inc (NASDAQ:ASMB) will stop working on its first-generation core inhibitor, vebicorvir (VBR), as it prioritizes its next-gen core inhibitors ABI-H3733 and ABI-4334 and advances its research pipeline.
- The decision follows the review of interim efficacy from the two triple combination studies that did not show a benefit in multiple key viral parameters compared to the combinations without VBR.
- Phase 1b trial of ABI-H3733 in chronic HBV infection is underway. Initial data are anticipated during 2H 2022.
- Assembly Bio will initiate a Phase 1a trial of ABI-4334 as single or multiple ascending dose administrations in healthy participants in 2H of 2022.
- The company will also prioritize its small molecule research programs and two additional viral targets to be introduced during Q3 2022.
- The company workforce will be reduced by approximately 30%.
- Luisa Stamm, the chief medical officer, will leave the company at the end of July, and Michael Samar, currently the CFO, will leave effective August 12.
- Assembly Bio has appointed Jason Okazaki as President & COO to oversee all general and administrative functions, including finance.
- The reprioritization and restructuring activities are expected to extend Assembly Bio’s estimated cash runway into 1H of 2024.
- Price Action: ASMB shares are up 5.53% at $2.29 during the premarket session on the last check Thursday.
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