- Alpine Immune Sciences Inc (NASDAQ:ALPN) announced clinical updates from ALPN-303 and davoceticept programs. Key highlights from the announcement include:
- ALPN-303
- Well tolerated in healthy adults when administered intravenously or subcutaneously at doses up to 960 mg.
- Pharmacodynamic analyses further support the feasibility of convenient subcutaneous therapeutic dosing every four weeks.
- Initial data from the basket studies in renal, hematologic, and dermatologic autoimmune diseases are expected in 2H of 2023.
- The company plans to conduct a phase 2 proof-of-concept study in systemic lupus erythematosus.
- Also Read: FDA Lifts Partial Hold On Alpine Immune’s Davoceticept Combo Trial In Advanced Cancer.
- Davoceticept (ALPN-202)
- Preliminary analyses of the NEON-2 trial of davoceticept plus pembrolizumab show a 37.8% reduction in prostate-specific antigen in castrate-resistant prostate cancer and a 25.5% reduction in tumor volume in poorly differentiated renal cell carcinoma (RCC).
- A third subject, with clear cell RCC, including prior primary resistance to nivolumab, achieved a durable confirmed partial response (-30%).
- Across the NEON-1 davoceticept monotherapy and NEON-2 studies, 2/5 (40%) and 3/5 (60%) of subjects have achieved a confirmed partial response or stable disease, respectively.
- Price Action: ALPN shares closed lower by 1.21% at $8.16 on Monday.
Why Chenghe Acquisition Stock Is Racing Higher
According to an SEC filing, Chenghe shareholders voted to approve the business combination with Taiwan Color Optics, Inc. dated July 21, 2023 with Taiwan Color Optics, Inc. Chenghe being the surviving company and will change its name to "Semilux Ltd."
