Applied DNA Sciences, Inc. (NASDAQ:APDN) (“Applied DNA” or the “Company”), a leader in PCR-based DNA technologies, today announced the general availability of Linea™ IVT platform evaluation kits (the “Kit”) and the first shipment of a Kit to an existing Linea™ IVT Template customer. The newly launched Kit, comprised of Linea™ IVT template, a buffer system, and Linea™ RNA Polymerase (RNAP), supports the conversion of current template evaluation customers to Linea IVT.
“The economics of Linea IVT are extremely compelling to us and are on the order of a 3-fold increase in contract value1 compared to equivalent standalone orders of Linea IVT templates,” stated Dr. James A. Hayward, president and CEO of Applied DNA. “As such, we are centrally focused on expanding our base of evaluation customers ahead of bringing online our cGMP-quality production capacity in early calendar year 2024 that we believe will lay the foundation for the platform’s commercial-scale contract awards.”
“Our recent receipt of commercial scale amounts of Linea RNAP and the availability of the Kit less than 7 weeks after the acquisition of Spindle highlights our ability to execute and our commitment to the Linea IVT platform,” concluded Dr. Hayward. “With large quantities of the RNAP in hand, we can now offer enough Kits to enable the manufacture of mRNA equivalent to approximately 233,000 COVID-19 30 μg vaccine doses1, which we believe is sufficient to service our current pipeline of evaluation customers.”
1Based on the Company’s internal modeling and estimates.
Linea™ IVT Platform
The Linea IVT platform combines cell-free, enzymatically produced Linea™ DNA IVT templates with its proprietary Linea RNAP to deliver multiple advantages over conventional mRNA production, including: 1) the elimination of plasmid DNA as a starting material; 2) the prevention or reduction of dsRNA contamination resulting in higher target mRNA yields; and, 3) the delivery of IVT templates in as little as 14 days for milligram scale and 30 days for gram scale.
