- 89bio Inc (NASDAQ:ETNB) announced the presentation of data from the ENTRIGUE Phase 2 proof-of-concept trial of pegozafermin in severe hypertriglyceridemia (SHTG) at the European Society of Cardiology Congress.
- Hypertriglyceridemia refers to an elevated level of triglycerides (a type of lipid) in the bloodstream, increasing the risk of coronary artery disease.
- Pegozafermin met its primary endpoint of statistically significant reductions in median triglycerides (TGs) from baseline across all dose groups compared to placebo after eight weeks.
- Related: This Analyst Thinks 89Bio’s Pegozafermin Data Has Exceeded Expectations.
- A sub-study of treated patients showed robust reductions in liver fat from baseline at week eight across all dose groups versus placebo.
- Further, 88% of treated patients vs. 0% of placebo patients achieved a ≥30% reduction in liver fat from baseline, and 24% of treated patients vs. 0% of placebo patients achieved normalized liver fat levels at week 8.
- Pegozafermin treatment also resulted in clinically meaningful improvements in non-HDL-C and apo-B, a key marker of cardiovascular risk and a direct measure of the number of atherogenic particles.
- Pegozafermin is currently being evaluated in the Phase 2b ENLIVEN trial in NASH and is expected to move into the Phase 3 program for SHTG in 2023.
- Price Action: ETNB shares are up 7.61% at $5.10 during the premarket session on the last check Friday.
Atkore International Gr Q4 Adj. EPS $5.52 Beats $5.08 Estimate, Sales $1.03B Beat $981.80M Estimate
Atkore International Gr (NYSE:ATKR) reported quarterly earnings of $5.52 per share which beat the analyst consensus estimate of $5.08 by 8.66 percent. This is a 25.74 percent increase over earnings of $4.39 per share
