Mirum Pharmaceuticals announced promising interim results from Phase 2b studies of volixibat for primary biliary cholangitis and primary sclerosing cholangitis. Significant improvements in pruritus and fatigue were observed.
- VANTAGE PBC interim analysis shows 3.8 point reduction from baseline and 2.3 point placebo-adjusted (p=0.0026) reduction in primary endpoint of pruritus- VISTAS PSC interim analysis exceeds efficacy threshold for study
Positive opinion from CHMP based on Phase 3 MARCH study with highly statistically significant (p<0.0001) reduction in pruritus severity between LIVMARLI vs. placebo across all PFIC types studied.CHMP assessment
Presented by Professor Richard J. Thompson, MD, King's College London, United Kingdom
Patients with PFIC showed significant and sustained improvements in pruritus severity, serum bile acid (sBA) levels, total
- Data demonstrate significant benefit across broadest range of genetic PFIC types ever studied- Significant improvements observed across multiple parameters including pruritus, serum bile acids, growth and