Corvus Pharmaceuticals Presents Soquelitinib Preclinical Data At Keystone Symposia On Systemic Autoimmune and Autoinflammatory Diseases

The poster presentation includes the first description of Corvus’ next-generation ITK inhibitor preclinical product candidates, which were designed to deliver precise T-cell modulation that is optimized for specific immunology indications. These preclinical product candidates exhibit specific biologic properties that are anticipated to enable more precise inhibition of Th1, Th2 and/or Th17 cell function. Atopic dermatitis (also called eczema) and asthma are thought to be mediated primarily by Th2 lymphocytes. Th17 cells are associated with psoriasis and psoriatic arthritis. A Th1 immune response is strongly implicated in rheumatoid arthritis and protection from many infections. The Venn diagram in Figure 1 illustrates the potential ability of various ITK inhibitor preclinical candidates developed by Corvus (I-number indicates individual compounds; SQL represents soquelitinib) to modify the differentiation of T cells. These results suggest that chemical structures may be refined to perform more specific biologic functions and may enable targeting of various disease types.