2024 Financial Guidance
Full year 2024 financial guidance is reiterated as follows:
| Combined net product revenues for ONPATTRO, AMVUTTRA, GIVLAARI and OXLUMO1 | $1,400 million – $1,500 million | |
| Net Product Revenue Growth vs. 2023 at reported FX rates1 | 13% to 21% | |
| Net Product Revenue Growth vs. 2023 at CER* | 13% to 21% | |
| Net revenues from collaborations and royalties | $325 million – $425 million | |
| GAAP R&D and SG&A expenses | $1,900 million – $2,050 million | |
| Non-GAAP R&D and SG&A expenses2 | $1,675 million – $1,775 million | |
| 1 Uses January 31, 2024 FX rates including: 1 EUR = 1.08 USD and 1 USD = 147 JPY | ||
| 2 Primarily excludes $225 – $275 million of stock-based compensation expense from estimated GAAP R&D and SG&A expenses | ||
| *CER = Constant Exchange Rate, representing growth calculated as if the exchange rates had remained unchanged from those used in the twelve months ended December 31, 2023. CER is a Non-GAAP measure. | ||
