Aligos Therapeutics To Present Data For Portfolio Targeting Chronic Hep B, NASH At The Liver Meeting Nov. 12-15

Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced upcoming poster

Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced upcoming poster presentations highlighting data relating to its chronic hepatitis B (CHB) and nonalcoholic steatohepatitis (NASH) clinical programs at The Liver Meeting® 2021, hosted by the American Association for the Study of Liver Diseases (AASLD), being held virtually November 12 – 15, 2021. 

All posters presented will be available on the Aligos website at Scientific Presentations & Conferences following the conclusion of the conference.

Chronic Hepatitis B

S-antigen Transport-inhibiting Oligonucleotide Polymers (STOPSTM)

Title: S-antigen Transport-inhibiting Oligonucleotide Polymers, (STOPSTM) Sequester Cellular Proteins to Reduce Hepatitis B Virus S-Antigen Expression and Increase Its Proteasomal Degradation
Publication Number: 845
Session Title: Hepatitis B: Therapeutics: New Agents
Presenter: C. Cheng Kao

Capsid Assembly Modulator (CAM)

Title: Safety, Pharmacokinetics (PK), and Antiviral Activity of the Capsid Assembly Modulator (CAM) ALG-000184 in Subjects with Chronic Hepatitis B (CHB)
Publication Number: 843
Session Title: Hepatitis B: Therapeutics: New Agents 
Presenter: Ed Gane

Antisense Oligonucleotide (ASO)

Title: Best-in-Class Antisense Oligonucleotides Against Hepatitis B Virus: Next Generation Bridged Nucleic Acid Chemistries Significantly Increase In Vivo Efficacy and Reduce Hepatotoxicity in Mice
Publication Number: 820
Session Title: Hepatitis B: Therapeutics: New Agents
Presenter: Dinah Misner

Title: ALG-020572, a GalNAc-Conjugated Antisense Oligonucleotide, Demonstrates In Vivo Efficacy and Favorable Preclinical Profile for the Treatment of Chronic Hepatitis B
Publication Number: 819
Session Title: Hepatitis B: Therapeutics: New Agents
Presenter: Kusum Gupta

siRNA

Title: Incorporation of Novel siRNA Chemistries Significantly Improves the Potency and Durability of HBV siRNAs in the AAV-HBV Mouse Model
Publication Number: 831
Session Title: Hepatitis B: Therapeutics: New Agents
Presenter: Jin Hong

Combinations

Title: Triple Combination of Anti-Hepatitis B Virus Drugs Demonstrates Synergistic Activity In Vitro
Publication Number: 852
Session Title: Hepatitis B: Therapeutics: New Agents
Presenter: Hua Tan

NASH

Title: Preclinical Pharmacokinetic Profiling of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta Agonist for the Treatment of Nonalcoholic Steatohepatitis, and Prediction of its Human Pharmacokinetics
Publication Number: 1932
Session Title: NAFLD and NASH: Therapeutics
Presenter: Kusum Gupta

Title: Development of a Novel Seven-Day Dosing Mouse Efficacy Model to Evaluate Thyroid Hormone Receptor Agonists for the Treatment of NASH
Publication Number: 1907
Session Title: NAFLD and NASH: Therapeutics  
Presenter: Xuan Luong

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